The Endocannabinoid System

is a naturally occurring biological system involved in regulating a variety of physiological processes throughout the body. This system works through activation of the CB1 and the CB2 receptors. Once activated by either a naturally-occurring endocannabinoid or a phytocannabinoid (plant-based cannabinoid) they trigger a biological response within the body.  CBD works indirectly on these receptors by preventing the breakdown anandamide which is the naturally occurring endocannabinoid responsible for activation of the CB1 and CB2 receptors.

 

The receptor locations can be seen when hovering or clicking on the body below.

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Thyroid - CB1, CB2

CBD, THC, CBN

Pancreas - CB1, CB2

CBD, THC, CBN

 

Bones - CB2, GPR55, TRPV1
CBD, THCv, CBN, CBG, CBC

 

Immune - CB1, CB2, TRPV1

CBD, THC, THCv, CBG, CBC, CBN

Liver -  CB1, CB2, TRPA1
CBD, THC, THCv, CBG, CBC

 

Vascular -  CB1, GPR18
CBD, THC, THCv, CBG, CBN

 

Brain - CB1, GPR18

CBD, CBDa, THC, THCv, CBN

Lungs -  CB1

CBD, THC, THCv, CBN

Gallbladder -  CB1, CB2
CBD, THC, CBN

 

Stomach - CB1, CB2

CBD, THC, CBN

Small Intestines - CB1, CB2

CBD, THC, THCv, CBN

Reproductive - CB1, GPR55, TRPV1
CBD, THC, CBC, CBG

 

Kidneys - CB1, CB2, TRPV1
CBD, THC, THCv, CBG, CBC

 

Muscles -  CB1, TRPA1
CBD, THC, THCv, CBC, CBN